Two-way radios, also known as transceivers, operate on specific frequencies and use specific protocols, so they may not be compatible with radios from different manufacturers or using different technologies. However, some radios are designed to be compatible with multiple frequencies and protocols, allowing them to work with a wider range of devices. It is important to check the specifications of the radios and ensure they are compatible before attempting to use them together.

BelFone DRM series radios are compatible with other manufacturers' DMR radios, such as Motorola and Hytera, but radios with different digital technologies such as DMR and P25 are usually incompatible with each other.